NIH R01 · 2024
Novel Roles of GRK2 and beta-arrestin2 on mast cell-mediated allergy and Inflammation
Summary: Mast cell (MC) activation through the aggregation of cell surface IgE receptors (FcεRI) leads to life- threatening conditions such as anaphylaxis and asthma. Recent exciting development in MC biology has been the discovery that they express a novel G protein coupled receptor (GPCR) known as MRGPRX2 (mouse counterpart MrgprB2), which contributes to a growing list of conditions such as pseudoallergy, neurogenic inflammation, non-histaminergic itch, allergic contact dermatitis and atopic dermatitis. The main objective of this proposal is to modulate FcεRI and MrgprB2-mediated responses by targeting novel signaling pathways in MCs. Following their activation, most GPCRs undergo…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.