NIH R01 · 2024
Direct Control of the human CMG Helicase by Myc and Rb
Abstract The replicative CMG (Cdc45-MCM-GINS) helicase plays functional roles during passage through the G1-S transition, DNA replication, and recovery from replicative stresses during S-phase. Evidence suggests that mis- regulation of the human CMG (hCMG) helicase by oncogenic pathways can contribute to the development of cancer through loss of cell cycle control and the creation of DNA damage. Although there is knowledge regarding the subunit composition and general functionality of the hCMG helicase during cell cycle progression, the molecular and biochemical mechanisms regulating the hCMG helicase directly by oncogenic pathways are poorly understood. We and others have shown that two…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.