Alexander-Bloch Lab

Children's Hosp of Philadelphia

Philadelphia · United States

NIH-funded
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NIH R01 · 2024

The Genetics of Personalized Functional MRI Networks

ABSTRACT Variability in the spatial layout of human brain functional networks on the anatomic cortex is a novel phenotype that can be extracted from functional magnetic resonance imaging (fMRI) with transformative potential for combined imaging-genetics studies of human brain function. Early results show that the individual-specific topography of Personalized Functional Networks (PFNs) is strongly associated with domains of psychopathology and cognition, including executive functioning (EF) which is impacted in multiple mental health conditions and undergoes profound changes during the period of adolescence. PFNs capture individualized aspects of brain function that have unique associations…

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