NIH R01 · 2024
Alzheimer's Prevention Initiative ADAD Colombia Trial Program
Project Summary/Abstract When the API Autosomal Dominant Alzheimer's Disease (ADAD) Colombia Trial (NCT01998841) was announced in 2012, it launched a new era in AD prevention research. The trial led us to identify ~6,000 persons from the world's largest ADAD kindred, including nearly 1,200 presenilin 1 (PSEN1) E280A mutation carriers, who are virtually certain to develop AD and become cognitively impaired at 44 (SD ± 5) years of age; establish the clinical trials, infusion capability, PET, and MRI infrastructure Colombia needed to conduct interventional studies in the kindred; and introduce precedent setting scientific, ethical, social support, and logistical paradigms as well as pioneering…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.