Alexander Lab

Pennsylvania State University, the

MISCELLANEOUS

University Park · United States

NIH-funded
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Research focus

NIH R01 · 2024

Mechanisms and interventions addressing accelerated cardiovascular disease risk in women with endometriosis

Endometriosis and is a debilitating estrogen-dependent gynecological disorder deriving from the presence of endometrium like tissue in sites outside the uterine cavity. Approximately 6-10% of women have endometriosis and suffer from symptoms including chronic pelvic pain, pain during intercourse, infertility, and other co- morbidities associated with systemic inflammation. The widespread nature of this disease extends to impact overall health, including contributing to elevated risk of cardiovascular disease (CVD) --the leading cause of death in women. Endometriosis and atherosclerotic CVD are both inflammation-induced diseases. Estrogen exposure is beneficial for women from a CVD…

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