NIH R01 · 2024
Lesion-centric optimization of multidrug therapies for tuberculosis
Modified Project Summary/Abstract Section Tuberculosis (TB) requires the simultaneous administration of multiple antibiotics to eradicate heterogeneous bacterial populations. Treatment duration ranges from 6 months for drug susceptible TB to 24 months and longer for extensively resistant TB. With a number of recent drug approvals and promising clinical development candidates, there is hope for much needed treatment shortening. However, we need high-throughput methods to rank the very large number of possible drug combinations and reduce them to a feasible number for testing in clinical trials. Currently, drug regimens are prioritized based on efficacy in the mouse model, which despite its…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.