NIH R01 · 2024
Summary/Abstract Although vaccination is the most effective measure for influenza prevention, there is considerable variation in the responses to influenza vaccines that is influenced by factors such as age, sex, and obesity level. Major advances in predicting and analyzing the cellular and molecular basis of vaccine responses are being made possible by the application of high-dimensional experimental and computational approaches that comprise Systems Vaccinology. This framework is yielding predictive molecular signatures for influenza vaccine immunogenicity and protection. However, there remains a considerable knowledge gap in delineation of cellular and molecular pathways that affect the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.