NIH R01 · 2024
Regulation of T cell immune response in Heart Failure with Preserved Ejection Fraction
The goal of this R01 application is to investigate the mechanisms by which T cells contribute to heart failure (HF) with preserved ejection fraction (HFpEF), affecting roughly 50% of the HF patients. Notably, the treatments that improve survival and outcomes in patients with HF with reduced ejection fraction (HFrEF) have not provided clinical benefit in HFpEF patients, who often present with multiple comorbidities that include obesity and hypertension. Correlative epidemiological studies in HFpEF patients, suggest a potential contribution of inflammation to HFpEF. However the underlying immune mechanisms remain largely unexplored. A unique myocardial hallmark of human HFpEF replicated in a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.