NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT During early human pregnancy, placental extravillous trophoblasts invade and remodel the uterine spiral arteries into distensible low-resistance vessels to promote placental perfusion and thus fetal development. A defect in uterine spiral artery remodeling (SAR) is the primum movens step that underpins adverse human pregnancy, particularly preeclampsia, which leads to systemic vascular dysfunction in and increased morbidity and mortality of the mother and offspring. However, there are no experimental primate models of defective SAR, noninvasive methods to detect the defect in SAR in early pregnancy or therapeutic modalities to prevent the maternal and offspring…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.