NIH R01 · 2025
EDGE CMT: Identifying genes that shape complex multigenic traits within and between yeast species
Most phenotypic traits, including nearly all morphological, physiological, and molecular quantities, vary continuously among individuals in a population. These traits are shaped by DNA variation at dozens to thousands of genes, giving them a complex, multigenic basis. Over the past 20 years, there has been remarkable progress in identifying genomic regions that are associated with complex traits. However, few of the causal genes that shape complex traits have been identified. This proposal addresses this key problem by introducing a new method for genetic mapping called CRI-SPA-Map. Our objectives are to apply CRI-SPA-Map in three distinct, complementary contexts in the yeast Saccharomyces…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.