NIH R01 · 2024
Abstract The exploration of genomes, transcriptomes, and proteomes derived from brains with Alzheimer's disease (AD) by powerful computational tools has developed new knowledge, including the identification of pathways and targets that may be involved in the initiation and/or progression of the disease. The challenge is to find drugs that impact those pathways and then validate the importance of those pathways – distinguishing primary disease drivers from secondary events. Repurposing FDA-approved drugs is one approach to probe potential pathways in proof of concept, and ultimately therapeutic, clinical trials. In this renewal application, we propose to discover and validate hypotheses for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.