NIH R01 · 2025
Antigen recognition and activation of HIV-specific B cell antigen receptors
Abstract B cell antigen receptor (BCR)-antigen interactions that govern the activation of B cells with a pre-vaccinated B- cell repertoire are not clearly defined for HIV-1 broadly neutralizing antibody (bnAb) lineages. Our recent studies show that B cell activation is dependent on antigen-binding association rate and not on the overall affinity (KD value), indicating that antigen sensing has a kinetic component. In this renewal application we will expand our studies to define the biophysical properties of antigen binding and cell surface interactions that lead to activation of B cells expressing germline precursor or early lineage intermediate BCRs of different HIV-1 bnAb specificities…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.