NIH R01 · 2025
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for patients with high- risk acute myeloid leukemia (AML). However, HSCT is affected by graft-versus-host disease (GvHD) and graft- versus-leukemia (GvL) effects, both are mediated by donor T lymphocytes and significantly impact treatment success and thus overall outcome. AML patients commonly harbor FLT3/internal tandem duplication (FLT3-ITD), a mutation in the receptor tyrosine kinase FLT3 that is associated with poor prognosis. FLT3 targeted therapies have proven clinical benefit particularly when used in combinational approaches. Midostaurin (a kinase inhibitor) was recently approved for…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.