NIH R01 · 2024
Epigenetic basis of retinal cell fate determination
SUMMARY: Progressive loss of retinal ganglion cells (RGCs) and subsequent degeneration of optic nerve is among the most common ophthalmic neuropathies that affect populations worldwide. A promising therapeutic strategy relies on using stem cells to reconstruct functional retinal ganglion cells in vitro that can be used to replace dying cells in affected patients. However, for this strategy to be successful, a thorough understanding to the molecular mechanisms of RGC specification and differentiation are needed to elucidate and exploit normal RGC developmental pathways and thereby maximize RGC generation for cell replacement therapies. Our previous work has mapped the epigenetic landscape…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.