Al Alam Lab

Research focus

NIH R01 · 2025

Cellular Senescence in Trisomy 21 lung disease

SUMMARY Trisomy 21 (T21) occurs in ~1 in 700 live births resulting in Down Syndrome (DS), where pulmonary complications are the main cause of hospitalizations in children and adults. These include tracheobronchial diseases presenting as decreased upper airway muscle tone, tracheobronchial malacia and airway obstruction with wheezing, particularly in babies and children. There is currently limited to no information regarding the pathogenesis of primary lung disease in DS. Thus, understanding early, perinatal factors leading to lung disease in neonates and children with DS becomes clinically relevant and innovative with potential for substantial lifelong impact. Senescent (Sen) cells in G1…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.