NIH R01 · 2024
Molecular Aspects of Tsetse and Trypanosome Transmission
This application is on prevention of African Trypanosomiasis, one of the most neglected diseases of Africa caused by parasitic African trypanosomes transmitted by tsetse. The absence of effective tools to curb infections in the mammal and the presence of animal reservoirs necessitate vector control to combat disease. We will investigate tsetse-trypanosome interactions that influence transmission dynamics. For transmission to occur, trypanosomes first establish infections in the midgut (MG) and then move to the fly's mouthparts to access and colonize the salivary glands (SG). The major barrier that eliminates parasites from the majority of flies occurs in the MG. We have shown that a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.