NIH R01 · 2025
PROJECT SUMMARY Effective wound care is of paramount importance for individuals who have sustained burn injuries. Wound healing is intricately associated with the sensations of itching and pain, which can significantly impact a patient's quality of life. Following a burn injury, monocyte-derived Langerhans cells (LCs) are mobilized from the bone marrow and recruited to the epidermal layer, potentially playing a pivotal role in the wound healing process. Furthermore, the sensations of itch and pain are largely mediated by the free nerve endings of nociceptive sensory neurons, often found in close proximity to resident LCs within the epidermis. However, our comprehension of how LCs modulate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.