NIH R01 · 2025
Molecular mechanisms of sympatho-excitation in cardiovascular disease
Project summary/abstract Cardiovascular disease is the leading cause of death worldwide, and overactivity of the sympathetic branch of the autonomic nervous system (sympatho-excitation) plays a key role in the pathogenesis or progression of numerous cardiovascular diseases. Overactivity of cardiac sympathetic neurons leads to increased release of neuropeptide Y (NPY), the major neuropeptide in the heart. Excess NPY release has been correlated with worse outcomes in heart failure, where it is speculated to be arrhythmogenic and contribute to sudden cardiac death. Our long-term goal is to understand what molecular changes occur within cardiac sympathetic neurons during sympatho-excitiation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.