NIH R01 · 2024
Skeletal Effects of Type 1 Diabetes
This application responds to the RFA titled, “Understanding Skeletal Effects of Type 1 Diabetes”, FOA RFA- DK-18-002. Low-trauma (osteoporotic) fractures are epidemic in the U.S. and the world(1-7). About 50% of the variation in risk of these fractures is due to low bone density, and the remaining 50% is due to defective mechanical properties of bone tissue(8). Diabetics suffer a significantly higher incidence of osteoporotic fractures than do non-diabetics(9-13), and their bone densities are higher at the time of fracture than in fracturing non-diabetic patients(13). These mechanical defects may be the result of episodes of hyperglycemia which could cause accumulation of compounds, such as…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.