Akerman Lab

University of Maryland Baltimore

OTHER BASIC SCIENCES

Baltimore · United States

NIH-funded
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NIH R01 · 2024

Molecular basis for functional S1PR1 antagonists in the treatment of comorbid migraine and temporomandibular disorders

Project Summary/Abstract Overlapping pain conditions greatly exacerbate patients’ pain experience. This includes comorbid migraine and temporomandibular disorders (TMDs), which is associated with a reciprocal increase in their prevalence/severity, increased risk of chronification, negatively impacting therapeutic outcomes. This underscores this comorbidity as a significant public health concern. However, little is known of its underlying pathobiology, highlighted by a dearth of validated animal models and a lack of evidence-based treatment approaches. Investigations into the underlying molecular mechanisms involved are therefore imperative, with the aim of identifying critically needed…

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