NIH R01 · 2025
Regulation and function of DNMT3A-mediated methylation in the brain.
Project Summary: The DNA methyltransferase DNMT3A is mutated in individuals with neurological disorders such as autism and intellectual disabilities. DNMT3A is highly expressed in the nervous system, primarily methylating atypical non- CG sequences, particularly at CA sites (mCA). The mCA mark is partially bound by MECP2, a protein mutated in Rett syndrome, which causes severe cognitive impairments. Deletions of either DNMT3A or MECP2 in the brain lead to significant gene expression defects and severe neurological and behavioral issues in mice. Despite the importance of mCA in brain function, its regulatory mechanisms and precise roles are largely unknown. Our lab has identified a novel…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.