Ajijola Lab

Research focus

NIH R01 · 2025

Satellite Glial Cell Activation and Sympathetic Imbalance in Cardiomyopathy and Arrhythmias

PROJECT SUMMARY/ABSTRACT Cardiac injury predisposes patients to heart failure (HF), and ventricular tachycardia/fibrillation (VT/VF). Development of HF and VT/VF after cardiac injury is tightly linked to sympathetic neural remodeling. Although several medications targeting cardiac sympathetic excess reduce mortality following cardiac injury, significant shortcomings of these drugs include off-target effects, limited efficacy, and focus on downstream consequences of neural remodeling such as excess catecholamine release, rather than preventing it upstream. In this proposal, we build on strong preliminary data from humans, porcine, and murine models demonstrating that satellite glial cell…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.