NIH R01 · 2025
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology
In this Yr16 renewal of our longitudinal study on the natural progression of AD biomarkers, the central goal remains to further understand the occurrence of asymptomatic amyloid-beta (Aβ) and tau deposition and the progression to clinical cognitive impairment. This cohort has now matured to the point that there is now sufficient longitudinal follow-up to address important hypotheses that were formulated from the beginning of this study but could not be properly addressed until 10-15 years of follow-up were in place - as is the case now. In this renewal period we aim to better characterize the different roles gray matter brain aging and small vessel disease have on AD progression.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.