NIH R01 · 2024
Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV
Project Summary Anti-retroviral therapy (ART) has protected many HIV patients against the development of AIDS. HIV infection has become a treatable disease. Increased risk for atherosclerotic vascular diseases in long-term HIV survivors or people living with HIV (PLWH) with no detectable virus load, however, is projected to become a global health burden. Despite its clinical impact, underlying mechanisms for accelerated atherogenesis in PLWH remain obscure. Macrophages promote the formation of high-risk plaques prone to vascular events (e.g., macrophage-rich, large necrotic core, think fibrous cap). Macrophages are heterogeneous and the imbalance of their subpopulations may accelerate…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.