NIH R01 · 2024
Engineered biomimetic collective cancer invasion models for screening chemotherapeutic agents
PROJECT SUMMARY Metastasis is the primary cause of cancer mortality, yet few breast cancer drugs effectively inhibit metastasis. Breast cancer cells use collective migration to remodel and align surrounding extracellular matrix (ECM) fibrils, which facilitates invasion. Aligned tumor stroma topography can induce cluster budding and dissemination of breast cancer cells. The goal of this project is to identify chemotherapeutic drugs using engineered biomimetic tumor invasion models and to evaluate therapeutic feasibility of inhibiting the target genes involved in breast cancer dissemination. To achieve this goal, we developed a quasi-3D nanotopographically patterned substrate and are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.