NIH R01 · 2024
A Cereblon signaling network in Wnt-driven cancers
A Cereblon Signaling Network in Wnt-driven Cancers Abstract The long-term objective of this study is to investigate how Cereblon (CRBN) regulates the Wnt signal transduction pathway and to demonstrate how this can be exploited to target Wnt-driven colorectal cancers (CRCs). Wnt signaling is essential for intestinal stem cell maintenance and aberrant activation of this pathway drives the initiation and progression of nearly all CRCs. To date, no drugs that inhibit the Wnt pathway have been FDA- approved, partly due to the lack of druggable targets that can bypass common Wnt pathway mutations in CRC. In a conceptual breakthrough, our recently published findings reveal that Cereblon (CRBN),…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.