NIH R01 · 2025
Chronic viral infections are characterized by a state of T cell dysfunction that is associated with expression of the PD-1 (programmed cell death 1) inhibitory receptor. A better understanding of the mechanisms that regulate CD8 T cell responses during chronic viral infection is required to improve immunotherapies that will increase T cell function and reduce viral load. We have recently identified a novel population of PD-1+ TCF-1+ virus specific CD8 T cells that act as stem cells to maintain T cell responses during chronic infection of mice with lymphocytic choriomeningitis virus (LCMV). The studies proposed in the application are focused on understanding how these virus specific…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.