Ahmed Lab

Research focus

NIH R01 · 2025

Metabolic regulation of Neutrophil Extracellular Traps (NETs) in TBI

Abstract: Traumatic brain injury (TBI) is a significant global public health issue, leading to high mortality rates, disabilities, and substantial socioeconomic burdens. TBI results in the loss of AMPKα activity, disruption in regional metabolism, persistent changes in metabolic rates and energy utilization, and elevated glycolysis which enhance the pentose phosphate pathway and promote inflammation. The association between metabolic changes in the brain tissue and the subsequent neutrophil activation and inflammation remains unclear. In this study, male/female C57BL/6 and AMPK-KO mice were subjected to CCI-induced TBI or sham surgery. After assessing behavioral impairments, the mice were…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.