NIH R01 · 2024
Cellular Plasticity and equilibrium in GBM Progression
PROJECT SUMMARY To advance our understanding of therapeutic resistance in Glioblastoma (GBM), it is essential to characterize the individual cell during therapy those fuel tumor recurrence in GBM. However, it is challenging to study the GBM during conventional radio- and chemotherapy due to limited accessibility to patient samples during this time period. Our lab performed a single-cell RNA sequencing screen in the patient-derived xenograft model of GBM during temozolomide (TMZ) therapy. Our analysis revealed that the Ribonucleotide Reductase Regulatory Subunit 2 (RRM2) mediates deoxynucleoside triphosphates (dNTPs) production necessary for proper DNA replication stable cell growth,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.