NIH R01 · 2025
Role of skeletal muscle IPMK in nutrient metabolism and exercise
SUMMARY Inositol phosphates are critical signaling messengers involved in a wide range of biological pathways in which inositol polyphosphate multikinase (IPMK) functions as a rate limiting enzyme for inositol polyphosphate metabolism. Many laboratories including ours have studied the biology of IPMK mostly in cellular models. IPMK has been implicated in metabolism but its tissue-specific function at the systemic level is poorly understood. IPMK is highly expressed in skeletal muscle, and the levels are increased with exercise and decreased in diabetes. Skeletal muscle is a major contributor to energy homeostasis, therefore, we have developed mouse and cellular models to elucidate metabolic…
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