NIH R01 · 2025
Using gene expression to identify patients at high risk for late breast cancer recurrence
PROJECT SUMMARY Non-metastatic breast cancer is treated surgically and with adjuvant therapies. As these treatments have improved, recurrence-free survival has steadily increased, and late recurrence (recurrence beyond 10 years’ survival) has become a pressing issue for patients and providers. There are existing and emerging therapies that prophylactically target dormant breast tumors to prevent late recurrence. However, these therapies carry substantial toxicities and should only be used in women who are at high risk for late recurrence. No prognostic assay is recognized by the American Society of Clinical Oncology or by the National Comprehensive Cancer Network to reliably predict…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.