NIH R01 · 2024
Oxylipin Signaling in Congenital Heart Disease
Project summary Congenital heart defects (CHD) constitute the most common type of congenital defect in humans, however the causes for CHD in most cases are unknown. Lipoxygenase-derived oxylipins are a complex and poorly characterized class of highly oxidized, polyunsaturated fatty acid-derived bioactive lipids with key biological activities. We recently found a link between oxylipin signaling, human cardiovascular development and CHD. This finding is critical not only because of the existing gap in knowledge, but also because oxylipins are strongly dietary-dependent. Our preliminary data suggests lipoxygenases and their oxylipin products dramatically modulate cardiogenic mesoderm formation…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.