Aguiar Lab

Research focus

NIH R01 · 2024

Oxidative stress and RNA methylation

N6-methyladenosine (m6A) is a prevalent chemical modification of RNA that influences gene expression and cell signaling. The levels of m6A are dynamically regulated by a RNA methyltransferase complex and by the alpha-ketoglutarate (αKG)-dependent RNA demethylases, FTO and ALKBH5. Misregulated RNA methylation, and its attendant effects on the epitranscriptome, has been associated with a host of human diseases, including obesity/diabetes, auto-immunity, neurodegeneration and cancer. Notably, these conditions can all develop in association with environmental factors that influence oxidative stress, e.g., atmospheric pollutants, cigarette smoking, ultraviolet rays, radiation, toxic chemicals,…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.