NIH R01 · 2025
Non-B DNA structure discovery and function assessment using nanopore translocation times
Abstract The canonical double helical structure of DNA (B-DNA) allows for stability and high-fidelity replication, but emerging evidence suggests an increasingly important role for non-canonical (or non-B) DNA structures in the cell. Non-B DNA structures have been (a) implicated in genetic disorders and carcinogenesis due to their increased mutability, (b) associated with variability in promotor activity, and (c) established as a substrate and site of localization for human telomerase and a putative mechanism for specifying centromere identity. Experimental discovery of non-B DNA structures requires specialized, low-throughput protocols that can be prohibitively expensive and typically…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.