NIH R01 · 2024
Project Summary Although induction of antigen-specific tolerance by means of targeting such antigens to dendritic cells (DCs) has been reported in multiple pre-clinical studies, there are currently no effective approaches using DCs in the clinic to prevent or reverse autoimmunity. DCs have been proven to intrinsically possess the ability to restore and maintain immune tolerance, making them very attractive candidates for treatment of autoimmune diseases. However, only non-activated DCs (which inherently possess a tolerogenic/suppressive phenotype) can induce tolerance, whereas activated DCs can trigger immunity. Notably, there is no strategy able to deliver antigen uniquely to non-activated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.