NIH R01 · 2025
UNDERSTANDING CADHERIN-11 IN THE DEVELOPMENT AND TREATMENT OF LUNG FIBROSIS
Project Summary/Abstract. Scleroderma (systemic sclerosis, SSc) is a progressive multisystem, autoimmune fibrotic disease with a high morbidity and mortality. SSc associated interstitial lung disease is a leading cause of death. Despite important advances in our understanding of SSc, treatment options remain limited. Identifying novel therapeutic targets for SSc is a major unmet need. Fibrosis, the cardinal manifestation of SSc, is the excessive extracellular matrix deposition, that damages the normal lung architecture and compromises the function of tissues. Our laboratory has identified cadherin-11 (Cdh11) as a novel regulator skin and lung fibrosis. How Cdh11 regulates fibrosis is not…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.