NIH R01 · 2024
ABSTRACT Enzymes have important implications for understanding many human diseases as well as for developing new medicines and therapies. Design of small molecule drugs without side-effects targeting enzymes and designer enzymes as biotherapeutics are widely pursued in the pharmaceutical industry. However, these endeavors are hindered, among other aspects, by the lack of fundamental understanding of enzyme function including the factors that enable enzymes to achieve high catalytic efficiencies. For more than a century, an immense wealth of information has been accumulated based on experimental and computational investigations. Collectively, the biochemical model of enzyme catalysis has…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.