Agarwal Lab

Indiana University Indianapolis

BIOSTATISTICS & OTHER MATH SCI

Indianapolis · United States

NIH-funded
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NIH R01 · 2025

SCH: Smart Breath- based Diagnosis of Pulmonary Exacerbations in Children with Cystic Fibrosis through Machine Learning: Towards Noninvasive Health Monitoring in Real-Time

Cystic fibrosis (CF) is a genetic disorder that negatively affects young people across the globe. Pulmonary exacerbations (PEx), episodes of decreased lung function accompanied by coughing, increased sputum production, and weight loss, are a hallmark of CF lung disease. Besides negative health impacts, PEx comes with a burden to healthcare costs in the United States and beyond ($10K-$40K USD per episode). Although PEx can be treated with antibiotics, patients still experience decreased quality of life and ultimately reduced survival. A point-of-care, rapid, and accurate test to identify impending PEx that would benefit from treatment could have an impact on families of children with CF and…

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