NIH R01 · 2025
Neuronal Regulation of Vascular Development and Maturation in the Retina
PROJECT SUMMARY Reciprocal interactions among neuronal, glial and vascular-associated cells are critical for proper vascular development (angiogenesis) and maturation [establishment of the blood-retina barrier (BRB)] in the early postnatal (P) retina. Although neuronal or glial cell-derived signals that promote angiogenesis and BRB formation2 are emerging, we do not understand how neuronal synaptic activity, in general, and which specific neurotransmitter(s), in particular, contribute to these processes. Nor do we know whether neurotransmitters act directly on endothelial cells (ECs) or indirectly via Müller glia. The superficial vascular plexus develops from P1-P9 during the spontaneous…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.