NIH R01 · 2025
Th17 extracellular trap-mediated antimicrobial host defense in acne vulgaris
PROJECT SUMMARY Acne vulgaris, or acne, is a disease of the pilosebaceous unit (PSU). Acne is ranked third among chronic skin diseases for causing disability and medical expense and is a major cause of psychological stress in young people. One factor contributing to acne is Cutibacterium acnes, the major bacterial species in the PSU. Using C. acnes as a model to study the interaction between the microbiome and the host immune response, we: 1) previously demonstrated the presence of IL-17 in acne skin lesions and 2) recently discovered that C. acnes phylotypes associated with acne (CA) or healthy skin (CH) differentially regulate the fate of TH17 cells to develop into non-antimicrobial…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.