NIH R01 · 2025
Abstract The intestinal pathogen Shigella flexneri is the causative agent of bacillary dysentery and is responsible for more than 250 million cases of dysentery annually, resulting in more than 200,000 deaths. The disease results from epithelial cell infection in the colon, leading to mucosal ulceration, vascular lesions and massive immune cell infiltration. Various animal models have been used to model various aspects of the disease, but none of these models recapitulated the colonic symptoms of human shigellosis. We have recently shown that infant rabbits experience all the symptoms of human shigellosis, including epithelial fenestration in the colon, vascular lesions, immune cell…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.