NIH R01 · 2025
Mitochondrial RNA Uridylation in Trypanosomes
SUMMARY Parasitic infections by Trypanosoma brucei spp. undermine public health and economy in Sub-Saharan Africa. From the basic science vantage point, discoveries of antigenic variation, trans-splicing, and RNA editing in these early branching protozoans have contributed fundamental tenets of eukaryotic biology. Notably, work on mitochondrial U-insertion/deletion mRNA editing introduced the guide RNA concept, a foundation of modern genome altering technologies. Identification of terminal RNA uridylyltransferases (TUTases) in trypanosomes has led to recognition of uridylation’s broad significance and diverse cellular roles, ranging from microRNA turnover in flies to maternal mRNA clearance…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.