Afacan Lab

Boston Children's Hospital

Boston · United States

NIH-funded
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Research focus

NIH R01 · 2025

Improved 3D EPI for Pre-Surgical Mapping of Epilepsy

Project Summary In pediatric epilepsy patients with drug-resistant seizures, surgical resection is the most effective treatment option. The goal of resective surgery is to maximize removal of epileptic foci to attain seizure-freedom while minimizing damage to surrounding brain regions to avoid permanent post-surgical functional loss. Functional MRI enables rapid and non-invasive pre-surgical mapping of language, motor skills and other critical functional brain regions with high spatial resolution. However, excessive head motion presents a major limitation for acquiring high-quality fMRI in pediatric patients with focal brain lesions, who usually have difficulty remaining still for long fMRI…

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