NIH R01 · 2025
Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids
ABSTRACT Uterine fibroids (leiomyomas) are the most widely observed tumors in women. By age 50, more than ~70% of white and more than 80% of black women develop at least one UF tumor. Although non-malignant, they disrupt normal uterine function and cause severe health problems ~25% of reproductive-age women. The most common subtype, representing ~70% of all fibroids, is caused by recurrent somatic mutations in the MED12 gene that encodes the mediator of transcription subunit 12 (MED12) protein. The lack of proper model systems hampered our mechanistic understanding of UF development and identifying effective treatment strategies. Our long-term goal is to interrogate the functional role of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.