NIH R01 · 2025
ABSTRACT Antibiotics are given universally to treat Crohn’s disease, especially with perianal fistulizing complications (PFC), which occur in about 1/3 of children. Decreasing the utilization is challenging, yet significant, as many guidelines support the use of antibiotics as first-line despite a lack of research showing benefit. Furthermore, there is such variation in treatment not only regarding antibiotic use but also around use of other medications, interventions such as drainage, and timing of each of these. In this innovative proposal, the investigators evaluate the current practices for management of PFC in Crohn’s disease at seven large pediatric institutions, develop a protocol to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.