NIH R01 · 2025
DNA Methylation Dynamics of Mammalian Development
PROJECT SUMMARY The progression from a pluripotent state into the myriad cell types that arise during mammalian development involves a host of epigenetic properties that dictate gene expression patterns and enforce the commitment of a cell to a specific lineage. The advent of single-cell genomics has enabled the study of cell lineage dynamics at unprecedented resolution; however, such studies have been largely limited to RNA transcription. The dynamic modulation of the epigenome that governs these processes involves multiple layers of regulation, including a major role by DNA methylation – a canonically repressive property that can act as a gatekeeper of genomic permissiveness. Aberrant DNA…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.