NIH R01 · 2024
Quantitation of Factors Regulating Glucose Tolerance
PROJECT SUMMARY Prevention, treatment, and cure of Type 2 diabetes requires understanding of the underlying causes, at the genetic and/or pathophysiological level. In our laboratory we have long been interested in identifying underlying causes leading to the disease. We have identified several underlying causes; in particular a reduction in insulin compensation for insulin resistance (lowered Disposition Index) and reduced insulin clearance. We have identified and additional potential factor – reduced Glucose Effectiveness (GE). The latter represents the ability of glucose itself to self-normalize (after oral or intravenous administration) independent of a dynamic insulin response. Yet the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.