NIH R01 · 2024
Probing the specificity and activity of the metazoan Integrator complex
Project Summary Precise control of gene expression in response to external signals and cues is essential for organismal development, growth, and homeostasis. A critical step in metazoan gene regulation involves pausing RNA polymerase II (RNAPII) in early elongation and its controlled release into productive RNA synthesis. Pausing of RNAPII consists of the association of pause-inducing factor NELF and the central scaffolding protein SPT5, which maintain RNAPII stably within the promoter region while awaiting the signal for pause release. Pause release is triggered by the kinase P-TEFb, which phosphorylates RNAPII and SPT5 to cause the dissociation of NELF and promote productive elongation.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.