Adeli Lab

Stanford University

PSYCHIATRY

Stanford · United States

NIH-funded
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Research focus

NIH R01 · 2024

Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia

PROJECT SUMMARY Alzheimer's disease and related dementias (AD/ADRD) rank prominently among age-associated neurodegenerative disorders, with Parkinson’s disease trailing as the second most common. Contemporary studies on AD and Mild Cognitive Impairment (MCI) have unveiled cognitive decline indicators mirrored in nuances within gait and hand movements. These indications often emerge long before AD or MCI diagnoses are confirmed. Consistently, research has correlated slowed gait with cognitive deterioration, elevated brain amyloid levels, and an augmented AD risk. However, the interplay between systems influencing both cognition and movement has largely been explored in separate studies. The…

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