Adelaiye-Ogala Lab

Research focus

NIH R01 · 2025

Posttranslational modifications of glucocorticoid receptor associated with drug-resistance in prostate cancer

PROJECT SUMMARY (ABSTRACT) An evolving concept that contributes to our understanding of resistance to androgen deprivation therapy (ADT) or androgen receptor (AR) antagonists in advanced prostate cancer (PCa) is the ability of cells to evade AR blockade and turn on compensatory hormone receptor signaling for survival. Preclinical and clinical studies by us and others have demonstrated that induction of glucocorticoid receptor (GR) expression confers resistance to AR-targeted therapy. Elegant studies by others in the hormone receptors field have shown that posttranslational modifications (PTM) on nuclear hormone receptors can amplify or alter their canonical activity to favor cancer cell…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.